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These cells often work synergistically, despite having distinct energy metabolism profiles (Table 1) (Blanger et al., 2011)

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Overall, the entry of drugs into the CNS depends on the pharmacokinetics (PK) parameters of drugs, such as molecular size, electric charge, lipophilicity, plasma protein binding, affinity to diffusion/active transport systems at the BBB and BCSFB, and pharmacodynamic (PD) factors such as CSF flow in the brain