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Without enough Vitamin B12, DNA making in megakaryocytes is disrupted

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Another RAMIRIS trial compared the safety and efficacy of FOLFIRI plus ramucirumab with paclitaxel plus ramucirumab for the same patients, and the results showed that FOLFIRI plus ramucirumab has a relative advantage in terms of the objective response rate (ORR), mPFS, and mOS (69)

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Topical evidence is stronger and includes IRB-approved human trials

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