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Gaggini et al

Statements Author contributions AH and KA: concept

All these pathological modifications contribute to the pathogenesis of vascular dysfunction

Front Immunol (2022) 13:916664

Regulatory bodies such as the FDA and EMA have implemented rigorous guidelines to address the specific challenges encountered with pulmonary nanotherapeutics, ensuring comprehensive preclinical evaluations including pharmacokinetics, biodistribution, and toxicity studies, with particular attention to lung-specific endpoints like alveolar inflammation and mucociliary clearance ( 2+ release (Sun et al., 2023)