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For example, in muscle, IRS-1 is more related to glucose uptake whereas IRS-2 stimulates the MAPK pathway [121]

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We find that Xpa-/- and Xpc-/- mouse livers accumulate mutations which we term SBS-NER-KO, a mutational signature resembling SBS8, which has an unknown mechanism but is likely driven by endogenous NER substrates

Specific BAs have been shown to directly influence the differentiation, activation, and effector functions of key innate and adaptive immune cell populations, highlighting a direct mechanistic link between microbial metabolism and anti-tumor immunity

Peeler C, Mirkovic D, Perles L, Titt U, Grosshans D, Mohan R

Hachette Book Group US Distribution and Fast-Growing Independent Childrens Publisher Nosy Crow Extend Partnership New York, NY, June 16, 2025 Hachette Book Group US Distribution and independent childrens publisher Nosy Crow have agreed to extend their US and Canada sales and distribution relationship, which began in 2023