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Most evidence comes from in vitro studies or small human trials, not large-scale randomized controlled trials

Mol Cell 2017, 67:962973.e5

Additionally, in contrast with methods that rely on passive cellular consumption for a particular modulator, the MPOC device predefines and enforces the concentration of all the modulators, and thus the metabolic pattern, to allow for a precise scientific study and hypothesis testing that goes beyond just recapitulating in vivo phenomena