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Involving in glucolipid metabolism Zincs role in insulin crystal formation is widely recognized, with insulin crystallizing in hexamers when two or more zinc atoms are present

To view a copy of this licence, visit About this article Cite this article Asai, C., Takamura, N., Watanabe, T

Considerations for Potential Applications of the AOP (optional) Addressess potential applications of an AOP to support regulatory decision-making.This may include, for example, possible utility for test guideline development or refinement, development of integrated testing and assessment approaches, development of (Q)SARs / or chemical profilers to facilitate the grouping of chemicals for subsequent read-across, screening level hazard assessments or even risk assessment

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Despite remarkable progress in our molecular understanding of amino acid transport, metabolism and signaling, it remains unclear by what mechanisms cytosolic amino acid concentrations are maintained