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A recipient of the 1997 The Nobel Prize in Economic Sciences for his groundbreaking work on the Black-Scholes-Merton model, he emphasized that true innovation arises from the coexistence of need, science, and technology

What we have is a lot of rat data

Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

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Roh JS, Sohn DH (2018) Damage-associated molecular patterns in inflammatory diseases

So the 100% figure is an assumption from how systemic administration generally behaves, not a measured number for this compound