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Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of amlodipine, particularly in patients with severe obstructive coronary artery disease

The 250500 mcg subcutaneous range used in current research contexts sits below the 1 mg clinical trial dose, partly because subcutaneous bioavailability differs from the oral administration used in some trial arms

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There was not enough evidence to explore the association between Met and GSH when used as adjunctive treatment, which needs to be evaluated in future studies