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Some chelators, such as D-penicillamine, also cause direct neurotoxicity, likely by crossing the blood-brain barrier and disrupting copper-dependent central nervous system enzymes, impairing energy metabolism, and increasing oxidative stress [245, 246]

Tenascin-C is an extracellular matrix glycoprotein that modulates cell adhesion and migration 41

It enhances anti-inflammatory/antibacterial capacity in IPECs and upregulates Claudin-1, EGFR, and IL-10 gene expression (95)

10.1152/ajpgi.00031.2015 113 RoychowdhuryS.McmullenM

Limitations in the literature Most studies have focused on aggressive statin therapy and the benefit of lowering LDL-C levels [11, 54, 55]

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