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These authors verified that creatine, at doses similar to those detected in plasma after supplementation, had an antioxidant cytoprotective activity on three cell lines against three different oxidative agents: H 2 O 2 , OONO and tert -butylhydroperoxide (tB-OOH)

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Studies in laboratory animals (minipigs, rodents, and dogs) have demonstrated the occurrence of cardiac arrhythmias and sudden death (with histologic evidence of myocardial necrosis) when agonists and methylxanthines were administered concurrently

doi: 10.1038/nrmicro3093 191 MaierB.KoomeyM.SheetzM

10.1016/j.freeradbiomed.2017.06.022 230

D.Alcocer-GmezE.Cano-GarcaF