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A further study validated that HDW alone or combined with arsenic trioxide could promote the total survival rate of BALB/c mice bearing WEHI-3 cells and the inhibitory effect on WEHI-3 cells in a dose-dependent manner

FIGURE 3 TABLE 2 Basic information on the top five degrees of the effective compounds in SJZD

Homer 1a, a postsynaptic scaffold protein, protects against traumatic brain injury by regulating mGluR1 and mGluR5

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Notably, vepdegestrant, supported by Phase 3 data in ER + /HER2 advanced breast cancer, has been submitted for FDA approval, positioning it as the potential first marketed PROTAC