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Type 2 diabetes mellitus A meta-analysis of 13 randomized, controlled feeding trials that substituted plant-derived PUFA (primarily linoleic acid [LA]) for saturated fatty acids or carbohydrates for 3 to 16 weeks in generally healthy adults showed a decrease in fasting insulin concentration and insulin resistance but no effect on fasting glucose concentration (123)

Again, comparing the experimental data to the pHp model using the same derived pKa of 6.78, for the fit a value of S o is used to fit the data that is again consistently low, 0.35uM

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Calibration and validation results As explained in the Methods section, we explored different grouping cases in forming the calibration and validation sets for the control and rd1 data

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