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A phase II clinical trial evaluating baricitinib for DKD treatment (181) found that, after 24 weeks, baricitinib significantly reduced the morning UACR and inflammatory markers, including urinary CCL2, serum TNF-R1, TNF-R2, and ICAM levels, compared to healthy controls

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Animal Model:Male Swiss-Webster mice (age 2 mo, body wt 25-30 g), a model of exercise-induced oxidative stress [2]

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