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Other SNPs in the study that correlated with stroke risk include GPX4, NOS1, and NOS2

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However, the following key messages give a summary for the use of vitamin C in clinical routine

Unlike at sites 1 and 2, where methionine residues provide axial coordination for CoPP, binding at site 3 appears to be mediated by axial chloride ligands 49 , which are stabilized through interactions with R313, Y431, and R435

Finally, as a proof-of-principle, we show that by replacing key structural motifs we could interconvert enzymatically active and inactive glutaredoxins, respectively