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These results led us to directly examine the benefits of NQO1 transgenesis (NQO1-Tg), and its contribution to improved insulin sensitivity and metabolic dysfunction by performing an integrated analysis of physiological data, histological changes, and omics profiles from serum and metabolically active tissues such as liver, skeletal muscle, and visceral fat in mice fed either standard diet (SD) or high-fat diet (HFD)

On the other hand, it is well-found that in vivo, macrophage activation occurs along with pro-inflammatory and anti-inflammatory conditions, with a degree of flexibility in both directions (Yamada and Kielian 2019)