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H 2 O 2 Treatment of GSNOR Results in Oxidative Modification of Multiple Cysteine Residues The thiol group of cysteine residues is susceptible to oxidation resulting in a formation of sulfenic, sulfinic, or sulfonic acids, the latter two are irreversible modifications

In patients with DME, intravitreal injections of VEGF antagonists and laser intervention are the current standard of treatment, but they are costly, have limited accessibility and must be administered repeatedly over time

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TNF- mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis

For endometriosis patients who have already experienced bone density reduction from GnRH agonist therapy, adding another potential contributor to bone loss requires careful monitoring