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For further prognostic evaluation and clinical decision-making, breast cancer can be classified into three subgroups based on immunohistochemical staining results for ER, PR, and HER2: HR-positive/HER2negative (HR+/HER2, ~70%), HER2positive (HER2+, ~1520%), and triple-negative breast cancer [TNBC, HR-negative (HR-), HER2, ~15%]

Finally, pernicious anemia is an autoimmune disease that affects B12 absorption and can result in a deficiency of this vital nutrient

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PMID 22948781

Mechanistically, we found that the early pro-ferroptotic effect of dexamethasone, mediated through system Xcdependent impairment of GSH biosynthesis [7], was subsequently overridden by reduced iron availability at later time points

doi: 10.1016/j.rmcr.2020.101063 27 IbrahimH