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Inhibition of the renin-angiotensin system and target organ protection

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However, even a 50% reduction in worm burden would decrease the human health problems caused by schistosomiasis, and a combination of auranofin (or another TGR inhibitor) with an agent that works by a different mechanism might be more effective and would also reduce the chances of the parasite developing drug resistance

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380 An experimental model fed with diet lack of prebiotic fiber induces hypertension through inducing deficiency of SCFA production and GPR43/109A signaling, suggesting the underlying mechanisms of dietary fiber