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However, this synergy remains mostly theoretical because human trials combining berberine with GLP-1 drugs are scarce

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It is important to note that a recent study has demonstrated a significant upregulation of NRF2, HMOX-1 and NQO-1 mRNA expression, as well as an increase in HMOX-1 and NQO-1 protein levels in the spinal cord of ALS patients (Lastres-Becker et al., 2022)

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Over the past decade, considerable progress has been made in directing ESCs toward primordial germ cell (PGC)-like cells and, under optimized conditions, toward functional gametes (193, 194)

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