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Some individuals experience neurological or fatigue-related symptoms before lab values fall below the deficiency range

and Looper, K.J., 2009

While Zn supplementation has shown potential to improve outcomes in some cases (Table 1), variability in results highlights the need for further mechanistic understanding of the reciprocal mechanistic regulation between Zn metabolism and IBD

Methotrexate slows down the progression [of inflammation] so it reduces the destruction of the joints. 2