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All of the animal studies were conducted on diabetic rats, including three studies on type 1 diabetic rats and six studies on type 2 [17,18,19,20,21,22,23,24,25]

It should be highlighted that, although short-term administration of celecoxib does not seem to alter the bacterial abundance, relative changes in some bacterial populations have been described although changes in butyrate production are not observed after its administration [337]

Oral supplements may cause mild digestive discomfort in some individuals, while injectable forms may involve risks such as local irritation at the injection site or allergic reactions in certain cases

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