Clinical evidence further substantiates lactate's pathological significance: urinary lactate levels in DKD patients show significant positive correlations with renal function indicators such as 24-h urinary albumin excretion and serum creatinine levels [35]
The protective effect of UA in parkinsonian model systems is also found to be dependent on Glut9-mediated transport, which is upregulated by UA in dopaminergic neurons in vitro 38
J Theor Appl Phys 11:119126
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Three-dimensional culture has been shown to more closely approximate the behaviour of the primary tumour 19
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