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Increased concentrations of its metabolites, such as leukotrienes, thromboxanes, and prostaglandins, are correlated with the severity of COPD

The excitation and depression of spinal neurones by structurally related amino acids

10.1038/s43018-023-00647-3 44 EngC

LPO is a key component of the innate immune system in the airways, and its inhibition leads to elevated H2O2 levels, which disrupts mitochondrial homeostasis, promotes epithelial cell senescence, and enhances the production of pro-inflammatory cytokines (Santiago et al., 2024)