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with MRP2 expressed in HEK293 cells 27 but is unable to transport doxorubicin (Fig

Cyclooxygenase (COX) pathway (Figure 1) Two cyclooxygenase isozymes (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandins, thromboxanes, and prostacyclin, which are mediators of inflammation, fever, and pain

Each workout produces an acute burst of reactive oxygen species (ROS) in muscle, which paradoxically triggers the cell's defense mechanisms a phenomenon known as mitohormesis ( 3.3 Physical capacity and metabolic health The systemic benefits of exercise in older adults extend to muscle strength, endurance, and metabolism

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