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Previous work on the eutylone metabolism is limited in scope, typically focusing on single-species, targeted metabolite lists, and lacking systematic enzyme confirmation or interaction assessment 16,17,18,19

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Clone with a Q45R substitution showed the best activity and was named G2 (Supplementary Fig

Nat Med (2013) 19:114752

By simultaneously targeting hepatic lipid metabolism (lipogenesis versus FA oxidation), insulin sensitivity, inflammatory amplification, and gut barriermicrobiome homeostasis, these interventions may more effectively address the multifactorial biology of MAFLD

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