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In the context of the so-called microbiotagutbrain (MGB) axis, it is shown to have a strong influence on host neuromodulation and endocrine functions (i.e., controlling the synthesis of neurotransmitters like serotonin or mediating the activation of the hypothalamicpituitaryadrenal axis), as well as in modulation of host immune responses, critically regulating intestinal, systemic and brain inflammation (neuroinflammation)

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In the next step, a proton is shuttled over to the nitrogen atom through deprotonation of oxygen and protonation of nitrogen

In contrast, secondary metabolites are compounds that are not needed for life, usually not only possessing a wide range of biological functions but also having special mechanisms of action (Li et al., 2021)

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Am J Manag Care 26(4 Suppl):S76-s84 Neubauer DN (2008) A review of ramelteon in the treatment of sleep disorders