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Notably, the Cu ion carrier-induced cell death pathway cannot be treated with inhibitors of other known cell death pathways, such as pan-cysteine aspartase inhibitors (anti-apoptotic compounds), Fe inhibitor-1 (an anti-Fe apoptotic compound), necrosin-1 (an anti-apoptotic compound), and N-acetylcysteine (an oxidative stress inhibitor), suggesting that cuproptosis mechanisms are distinct from previously identified cell death pathways, e.g

Recent research has unveiled that lactate can facilitate the lysine lactylation (Kla) of core histone proteins, thereby modulating gene expression (e.g., Arg1) and influencing the pathogenesis of various conditions, such as tumor formation [16, 21] (Fig

Isotopic tracer, C 1 3

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Role of STAT3 signaling pathway in breast cancer

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