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Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)

PMID 21204284

used a transgenic approach to carry out similar gain- and loss-of-function experiments in the developing mouse cochlea in vivo (Shi et al., 2014)

As with any supplement, periodic breaks (three months on, one month off) are a reasonable precautionary approach, particularly for individuals with no confirmed deficiency or elevated oxidative stress markers

Journal of Oral Rehabilitation 47(2):150157 Chojnacki C et al (2022) Altered tryptophan metabolism in patients with recurrent functional abdominal pain

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