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A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice

Machado ND, Heather LC, Harris AL, Higgins GS

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Owing to their multi-target and synergistic pharmacological mechanisms, such as anti-inflammatory, membrane-stabilizing, antioxidant, anti-apoptotic, and immunomodulatory effects, they have demonstrated clear efficacy in the clinical treatment of various liver conditions, including viral hepatitis, drug-induced liver injury, and alcoholic liver disease

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Two predicted drugs (gemcitabine and cladribine) and one NO-based drug (diphenyleneiodonium) have a reported median IC 50 below 0.4 M in melanoma cell lines, this being comparable to known anti-melanoma drugs (Supplementary Fig