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It plays a crucial role in: Neutralizing free radicals Detoxifying the liver Strengthening the immune system Supporting cellular repair As more people seek glutathione for skin whitening , anti-aging, and health improvement, it is critical to understand its interactions to avoid unwanted side effects

Abbreviations ROS: Reactive oxygen species NIHL: Noise-induced hearing loss HC: Hair cell TTS: Temporary hearing threshold shift ANF: Auditory nerve fiber PTS: Permanent threshold shift OHC: Outer hair cell SGN: Spiral ganglion neuron DAMP: Damage-associated molecular pattern TLR: Toll-like receptor RAGE: Receptor for advanced glycation end product NOX: NADP oxidase ETC: Electron transport chain PRX: Peroxiredoxin GPX: Glutathione peroxide SOD2: Superoxide dismutase 2 mtROS: Mitochondrial ROS MAPK: Mitogen-activated protein kinase JNK: C-Jun N-terminal kinase MAPKK: MAPK kinase MAPKKK: MAPKK kinase Keap1: Kelchlike ECHassociated protein 1 Nrf2: Nuclear factor erythroid 2related factor 2 ARE: Antioxidant response element HO-1: Haem oxygenase-1 NAD(P)H: Nicotinamide adenine dinucleotide phosphate ABR: Audit brain response References Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC

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How does the blood-brain barrier function