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Chronic hyperglycemia induces excessive accumulation of advanced glycation end products (AGEs), enhanced oxidative stress, activation of inflammatory responses, and aberrant activation of the renin-angiotensin system (RAS)

Hyams, C., Camberlein, E., Cohen, J

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Antioxidants (Basel, Switzerland) , 11 (7), 1374

J Appl Physiol (2006) 100:15206

Additionally, dysbiosis may compromise intestinal barrier integrity, resulting in microbial translocation, commonly referred to as leaky gut, where microbial components (e.g., LPS, fungal antigens) enter the bloodstream [40,43,68,69,70]