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Another example is runt-related transcription factor (RUNX2), a master regulator of bone development, which drives the osteogenic differentiation in VSMCs, leading to plaque calcification process [48]

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Upon irradiation with visible light (410 nm), PPIX generates reactive oxygen species (ROS) 24 , which oxidizes Met to Met sulfoxide (MetO), thereby rebalancing noncovalent forces driving a morphological transition from nanofibers (NFs) to spherical nanoparticles (NPs)