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Potential risks include: Insulin resistance Fluid retention Carpal tunnel-like symptoms Theoretical cancer signalling concerns with chronic GH elevation Unknown long-term effects Absence of long-term harm data is not the same as proof of safety

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LDHA KD did not appear to affect STAT1 expression or the sensitivity to the ferroptosis inducers RSL3 and Erastin in A549 and H838 cells ( Supplementary Figure 5a, b, c ), as did the LDHA inhibitors (GSK2837808A and R-GNE-140) ( Supplementary Figure 5d, e ), suggesting that LDHA is not involved in ferroptosis surveillance in KRAS-mutant NSCLC

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