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Further studies documented that NTBC was a potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPD), which catalyzes conversion of 4-hydroxyphenylpyruvate to homogentisic acid 53 (Figure 1)

Metabolic effects of nicotinamide administration in rats

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Ogu UO, Thomas M, Chan F, Vattappally L, Sebastian G, Crouch A, You S, Minniti CP (2021) L-glutamine use in adults with sickle cell disease: clinical trials where success meets reality

Current Western medical treatment is based on disease-modifying anti-rheumatic drugs (DMARDs) (4), but there are problems such as insufficient efficacy, drug resistance and adverse reactions, and the clinical outcomes of RA patients are not satisfactory (3)

She later developed a passion for immunology by conducting research on type I diabetes during a summer internship at the Harvard Medical School affiliate Joslin Diabetes Center