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In several animal studies, creatine has been shown to provide protection against neurodegenerative diseases

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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

Additional References

This effect is due to the regulation of IL-17 production, which is closely related to the progression of the encephalopathy [61]