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Cohort 2 will be for PD participants who are receiving deep brain stimulation (DBS) treatment

Nat Genet 55:255267

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The misfolding and aggregation of -synuclein into insoluble fibrils is a pathological hallmark of PD

While it may look clear, its effectiveness could be drastically reduced, which would invalidate any research data collected using it

( Reference Dutta, Seirafi and Halpin 39 ) , although riboflavin deficiency alone did not affect the activities of GPx and GR and increased the content of glutathione in the liver, ethanol administration (which can exacerbate oxidative stress) significantly decreased the activities of these enzymes and the content of glutathione in the liver of riboflavin-deficient rats compared with those in the liver of the riboflavin-sufficient control rats