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[Abstract]2026 May 14:115062

Carbon monoxide (CO) is an inorganic chemical compound that can bind with a multitude of hemoproteins, boasting at least 25 identified targets, including hemoglobin, myoglobin, neuroglobin, cytochrome c oxidase, cytochrome P450, soluble guanylyl cyclase, myeloperoxidase, and several ion channels, with dissociation constant values ranging from sub-nM to high M ( (HIF 1) and nuclear factor erythroid 2-related factor 2 (Nrf2), inhibit poly (ADP-ribose) polymerase (PARP) cleavage, reduce caspase-3 activation, inhibit cell death, and activate the release of adenosine by astrocytes (Zhang et al., 2011

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