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AgC10, a mucin from Trypanosoma cruzi , destabilizes TNF and cyclooxygenase-2 mRNA by inhibiting mitogen-activated protein kinase p38

While hydroquinone is considered the gold standard for lightening dark spots, its results are significantly enhanced when combined with other proven ingredients like tretinoin, which speeds up cell turnover, and a mild corticosteroid, which reduces inflammation and irritation

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However, clinical translation has been challenging due to delivery issues and side effects

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The role of the commensal gut microbial community in broiler chickens