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We also analyzed the levels of aspartate transaminase (AST) and alanine transaminase (ALT) after hepatocyte injury

Given the prior benefits we observed for NAC in our Seahorse assays, we tested if NAC could restore intracellular GSH, which it did (Fig

Beclin-1 Overexpression in cases with resected stage II and stage III colon carcinomas, who received 5-FU-based therapy was associated with worse OS, denoting a potential effect of autophagy in drug resistance (29)

Although rips-1 was not found in the study, we reasoned that due to the regulation of its paralogues by H 2 S and the similarities in DTT, -mercaptoethanol, and H 2 S, rips-1 may also respond to H 2 S

doi: 10.1038/s41598-022-11236-2 Summary Keywords metformin, rectal cancer, colorectal, radiosensitiser, energy metabolism, radioresistance Citation Buckley CE, OBrien RM, Nugent TS, Donlon NE, OConnell F, Reynolds JV, Hafeez A, ORordin DS, Hannon RA, Neary P, Kalbassi R, Mehigan BJ, McCormick PH, Dunne C, Kelly ME, Larkin JO, OSullivan J and Lynam-Lennon N (2023) Metformin is a metabolic modulator and radiosensitiser in rectal cancer