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Thymosin beta-4 is not used medically

DIM has been associated with drug rash with eosinophilia and systemic symptoms (DRESS), a severe and potentially fatal drug reaction

In a single-center case-control study, Buso et al

These inhaled insulin programmes, although eventually discontinued following the market challenges of Exubera 246 laid important groundwork for engineering inhalable biologics and other therapeutics aimed at systemic administration with a need for accurate control over systemic exposure

J Exp Bot 72:64476466

For instance, treatment with SGLT2 inhibitors results in a decline in long-chain acylcarnitines that parallels improvements in mitochondrial function and correlates with a slower rate of eGFR decline [168], suggesting that these metabolites can serve as sensitive pharmacodynamic biomarkers