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IgG DGP are particularly useful in identifying CD in early childhood (age 80% of the neoplasm) it is possible to use biologic therapy with anti-CD30 associated with monomethyl auristatin E (brentuximab vedotin) and a chemotherapy regimen containing cyclophosphamidedoxorubicinprednisone followed by autologous stem cell transplantation [159]

The cause is usually a deficiency of either cobalamin (vitamin B 12 ) or folate, but megaloblastic anemia may arise because of genetic or acquired abnormalities affecting the metabolism of these vitamins or because of defects in DNA synthesis not related to cobalamin or folate

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10.1016/j.molliq.2021.116104 136 NevaT.CarmonaT.BenitoJ

Participants were grouped according to office SBP, irrespective of antihypertensive medication

Zhao BC, Zhao B, Han JG, Ma HC, Wang ZJ