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Schmitz and colleagues [76] demonstrated that the IP3R is co-activated by IP3 and calcium ions and is potentiated by ATP

Specifically, linking ONs - such as antisense oligonucleotides (ASOs) or short-interfering RNAs (siRNAs)to proteins or peptides can enhance properties like cell-specificity and cellular uptake 6 , which remain significant hurdles for many ON therapeutics