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We first [7] introduced the "cocktail treatment," in which a gelatin sponge was impregnated with ropivacaine, dexamethasone, and vitamin B12 into percutaneous endoscopic lumbar disectomy (PELD), and observed that the method indeed shortens the duration of recovery and lends better clinical outcomes

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The alternative route involves choline metabolism, where choline is sequentially converted into betaine, dimethylglycine, sarcosine, and finally glycine through the action of specific enzymes (Wang et al

Watanabe LM, Pereira V, Noronha NY, de Souza Pinhel MA, Wolf LS, de Oliveira CC, et al

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