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Found endogenously in human plasma (~200 ng/mL at age 20), saliva, and urine, GHK-Cu forms a high-affinity complex with copper(II) ions through its histidine imidazole nitrogen and peptide backbone coordination

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However, pyruvate can enter mitochondria for further catabolism processes, in which case the full process, cytosolic glycolysis and pyruvate oxidation, is called glucose oxidation