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MazzantiGMenniti-IppolitoFMoroPACassettiFRaschettiRSantuccioCet al

As a master transcriptional factor, nuclear factor erythroid 2-related factor 2 (NRF2) plays a key role in the regulation of an extensive panel of antioxidant response elements (ARE)-related genes including superoxide dismutase (SOD), catalase (CAT), glutamate-cysteine ligase catalytic subunit (GCLC) and glutamatecysteine ligase regulatory subunit (GCLM), NAD(P)H: quinone oxidoreductase-1 (NQO-1) and heme-oxygenase-1 (HO-1) 7,8

One such study that compared fibromyalgia patients with healthy controls showed a significant difference in cerebral pain processing due to polymorphisms in the mu-opioid receptor gene