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These findings currently lack clinical confirmation in human trials

Therefore, increased research attention on the effects of these micronutrients is warranted

Remarkably, abrogation of the K133:D129 electrostatic interaction (IL-1 K133A and IL-1 D129A point mutations) increased IL-1 stability even further (Fig

doi: 10.1104/pp.94.3.1496 75 SawakeS.TajimaN.MortimerJ

As a direct consequence of this enhanced PHGDH activity, murine models demonstrate that augmented serine biosynthesis fuels glutamine utilization to drives intestinal tumorigenesis (192)