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14 Because O 2 is an obligatory substrate for PHDs, HIFs escape PHD-dependent hydroxylation under hypoxic conditions, translocate to the nucleus and dimerize with the subunit (also termed ARNT), and through binding to hypoxia-response elements in promoter regions of target genes, activate the transcription of its target genes (Figure 1)

Cell Metabolism, 25(2), 242-247

While the study by Mavalli et al

Eur Arch Psychiatry Clin Neurosci

The modified paper-based electrode showed a stable cyclic voltammetric response in an analyte concentration range from 3.5 nM to 3.5 mM

In the classical ferroptosis regulatory pathway, GSH is depleted by erastin or other system Xc- inhibitors, which reduces cysteine synthesis and leads to GSH synthesis disorder [2, 72, 73]