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WTX and PALB2 may suppress carcinogenesis partly through maintaining the Nrf2 activity for cytoprotection

This method is often used for addressing conditions like chronic fatigue, cognitive decline, and addiction recovery

A recent study has demonstrated that an acute increase in the intracellular concentration of ROS inhibits the glycolytic enzyme pyruvate kinase M2 (PKM2) through the oxidation of Cys358 (Anastasiou et al., 2011)