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As a master upstream kinase, LKB1 phosphorylates and activates AMPK and many other kinases that play a fundamental role in the regulation of cell growth and metabolism [301]

These pathways are closely linked to core AD pathologies, including A aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress and mitochondrial dysfunction

Knock-out mice lacking the Folr1 folate receptor showed this through their inability to reproduce due to embryogenesis failure

Once in the blood, it travels throughout the body and reaches the digestive tract

doi: 10.1016/S0140-6736(18)31376-X

Erez Z, Steinberger-Levy I, Shamir M, Doron S, Stokar-Avihail A, Peleg Y, et al