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Vitamin B12 injections, commonly prescribed for pernicious anaemia or malabsorption, can produce supraphysiological levels that persist for weeks

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We also demonstrate that SCLC cells associated with high ASCL1 expression are more susceptible to the blockage of mitochondrial respiratory complex I (NADH dehydrogenase) and, moreover, that non-ASCL1-driven cells are more susceptible to glutaminolysis inhibition, which may allow future subtype-specific personalized therapy

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Wang DY, Done SJ, Mc Cready DR, Leong WL

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C.JoudoiT.KawataniJ.ShigiharaY.et al (2015)

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